The X-Arcade™ is natively supported by the OUYA™ game console and simply acts like a single game pad. This means it will work in the menus and in supported software. Unfortunately however, the OUYA™ developers made both players on a dual/Tankstick™ controller both act like the same controller, so you can't play 2-player games this way. One way to work around this limitation is to instead use 2 of our Xbox™ 360 adapters along with a USB hub instead.
The trackball also works on it as a mouse. For a Tankstick™ you will need to use a USB hub to connect both USB connections.

RetroArch™
RetroArch™ allows you to play many emulators all from one app, including MAME™ games. Due to the limitiation mentioned at the top of this article, you will need to use 360 adapters to play 2-players however.
MAME4Droid
MAME4Droid on the Ouya™ store only works with one gamepad, meaning you can't play 2-player games at all currently (as of version .139). We recommend that you simply use Retroarch™ instead.